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Not all people with CLL call for therapy. In spite of all recent innovations, the iwCLL nevertheless suggests watchful observation for patients with asymptomatic disorder.86 This advice is based on no less than two randomized trials evaluating observation to possibly chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR).103,104 The two trials concluded that early therapy in asymptomatic clients was not linked to a chronic In general survival.

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) and incorporated into these prognostic devices, but none of these attempts succeeded in starting to be common of treatment.94–96 In fact, the International Workshop on CLL (iwCLL) suggestions only endorse evaluating the IGHV status and presence/absence of TP53 aberrations in regime practice.

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